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Biomaterials for spinal cord regeneration: outgrowth of presumptive neuronal precursors on electrospun poly(epsilon)-caprolactone scaffolds microlayered with alternating polyelectrolytes.

Thouas, George A.; Contreras, Karla G.; Bernard, Claude C; Sun, Gui Zhi; Tsang, Kelly M; Zhou, Kun; Nisbet, David; Forsythe, John S.


The aim of this study was to assess the feasibility of electrospun poly(epsilon)-caprolactone (PCL) scaffolds treated with alternating paly-electrolytes as a controllable three-dimensional adhesive substrate for neuronal progenitors. Unmodified PCL surfaces were generally not supportive of mouse embryonic stem cell (mESC) colony adhesion. However, scaffolds surfaced using layer-by-layer (LbL) deposition of heparin/poly-L-lysine encouraged better local adhesion of mESC colonies, and networking...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: IEEE Engineering in Medicine and Biology Society: Conference Proceedings


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