Hernias and Ewings sarcoma family of tumours: a pooled analysis and meta-analysis
Date
2005
Authors
Valery, Patricia C
Holly, Elizabeth A
Williams, Gail
Kreiger, Nancy
Bailyn, C
Sleigh, Adrian
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Lancet Publishing Group
Abstract
Background: Ewing's sarcoma family of tumours has been associated with a history of hernia and with a parental occupation of farming. However, the causes of these tumours remain unknown. We therefore aimed to investigate the association between hernia and Ewing's sarcoma family of tumours. Methods: We did a pooled analysis of two case-control studies and a meta-analysis of three case-control studies of Ewing's sarcoma family of tumours that had adequate information on history of hernia. The primary endpoint was development of a tumour from the Ewing's sarcoma family. 138 patients with such a tumour and 574 controls were included in the pooled analysis, and 357 patients with these tumours and 745 controls were included in the meta-analysis. Risk was assessed by an odds ratio (OR) and 95% CI by use of multivariate analysis with unconditional logistic regression for the pooled analysis and random effects model for the meta-analysis. Findings: Pooled analysis showed that children with Ewing's sarcoma family of tumours were more likely to have had an umbilical hernia than were controls (odds ratio [OR] 3·3 [95% CI 1·3-8·0]). Meta-analysis showed that children with Ewing's sarcoma family of tumours were more likely to have had a hernia (3·2 [1·9-5·7]). Interpretation: Ewing's sarcoma family of tumours and hernias (particularly inguinal hernias) have common embryological pathways of neuroectodermal origin, and environmental factors, such as farming, might link the two entities.
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Keywords: agricultural worker; article; case control study; clinical trial; confidence interval; controlled clinical trial; controlled study; disease association; environmental factor; Ewing sarcoma; hernia; human; information retrieval; inguinal hernia; logistic r
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Lancet Oncology, The
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Journal article
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2037-12-31
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