Hernias and Ewings sarcoma family of tumours: a pooled analysis and meta-analysis
dc.contributor.author | Valery, Patricia C | en_AU |
dc.contributor.author | Holly, Elizabeth A | en_AU |
dc.contributor.author | Williams, Gail | en_AU |
dc.contributor.author | Kreiger, Nancy | en_AU |
dc.contributor.author | Bailyn, C | en_AU |
dc.contributor.author | Sleigh, Adrian | en_AU |
dc.date.accessioned | 2015-12-13T22:49:36Z | |
dc.date.issued | 2005 | |
dc.date.updated | 2015-12-11T10:36:39Z | |
dc.description.abstract | Background: Ewing's sarcoma family of tumours has been associated with a history of hernia and with a parental occupation of farming. However, the causes of these tumours remain unknown. We therefore aimed to investigate the association between hernia and Ewing's sarcoma family of tumours. Methods: We did a pooled analysis of two case-control studies and a meta-analysis of three case-control studies of Ewing's sarcoma family of tumours that had adequate information on history of hernia. The primary endpoint was development of a tumour from the Ewing's sarcoma family. 138 patients with such a tumour and 574 controls were included in the pooled analysis, and 357 patients with these tumours and 745 controls were included in the meta-analysis. Risk was assessed by an odds ratio (OR) and 95% CI by use of multivariate analysis with unconditional logistic regression for the pooled analysis and random effects model for the meta-analysis. Findings: Pooled analysis showed that children with Ewing's sarcoma family of tumours were more likely to have had an umbilical hernia than were controls (odds ratio [OR] 3·3 [95% CI 1·3-8·0]). Meta-analysis showed that children with Ewing's sarcoma family of tumours were more likely to have had a hernia (3·2 [1·9-5·7]). Interpretation: Ewing's sarcoma family of tumours and hernias (particularly inguinal hernias) have common embryological pathways of neuroectodermal origin, and environmental factors, such as farming, might link the two entities. | |
dc.identifier.issn | 1470-2045 | |
dc.identifier.uri | http://hdl.handle.net/1885/80615 | |
dc.publisher | Lancet Publishing Group | |
dc.source | Lancet Oncology, The | |
dc.subject | Keywords: agricultural worker; article; case control study; clinical trial; confidence interval; controlled clinical trial; controlled study; disease association; environmental factor; Ewing sarcoma; hernia; human; information retrieval; inguinal hernia; logistic r | |
dc.title | Hernias and Ewings sarcoma family of tumours: a pooled analysis and meta-analysis | |
dc.type | Journal article | |
local.bibliographicCitation.lastpage | 490 | |
local.bibliographicCitation.startpage | 485 | |
local.contributor.affiliation | Valery, Patricia C, Queensland Institute of Medical Research | |
local.contributor.affiliation | Holly, Elizabeth A, University of California | |
local.contributor.affiliation | Sleigh, Adrian, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Williams, Gail, University of Queensland | |
local.contributor.affiliation | Kreiger, Nancy, University of Toronto | |
local.contributor.affiliation | Bailyn, C, Yale University | |
local.contributor.authoremail | u4052332@anu.edu.au | |
local.contributor.authoruid | Sleigh, Adrian, u4052332 | |
local.description.embargo | 2037-12-31 | |
local.description.notes | Imported from ARIES | |
local.description.refereed | Yes | |
local.identifier.absfor | 111706 - Epidemiology | |
local.identifier.ariespublication | MigratedxPub8874 | |
local.identifier.citationvolume | 6 | |
local.identifier.doi | 10.1016/S1470-2045(05)70242-4 | |
local.identifier.scopusID | 2-s2.0-21344453299 | |
local.identifier.uidSubmittedBy | Migrated | |
local.type.status | Published Version |
Downloads
Original bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- 01_Valery_Hernias_and_Ewings_sarcoma_2005.pdf
- Size:
- 115.27 KB
- Format:
- Adobe Portable Document Format