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Copper-induced conformational change in a marsupial prion protein repeat peptide probed using FTIR spectroscopy

Gustiananda, Marsia; Haris, Parvez I; Milburn, Peter J; Gready, Jill

Description

We report the first Fourier transform infrared analysis of prion protein (PrP) repeats and the first study of PrP repeats of marsupial origin. Large changes in the secondary structure and an increase in hydrogen bonding within the peptide groups were evident from a red shift of the amide I band by >7 cm-1 and an approximately five-fold reduction in amide hydrogen-deuterium exchange for peptide interacting with Cu2+ ions. Changes in the tertiary structure upon copper binding were also evident...[Show more]

CollectionsANU Research Publications
Date published: 2002
Type: Journal article
URI: http://hdl.handle.net/1885/65421
Source: FEBS Letters
DOI: 10.1016/S0014-5793(01)03298-7

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