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Copper-induced conformational change in a marsupial prion protein repeat peptide probed using FTIR spectroscopy

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dc.contributor.authorGustiananda, Marsia
dc.contributor.authorHaris, Parvez I
dc.contributor.authorMilburn, Peter J
dc.contributor.authorGready, Jill
dc.date.accessioned2015-12-10T23:17:57Z
dc.date.issued2002
dc.date.updated2015-12-10T10:02:43Z
dc.description.abstractWe report the first Fourier transform infrared analysis of prion protein (PrP) repeats and the first study of PrP repeats of marsupial origin. Large changes in the secondary structure and an increase in hydrogen bonding within the peptide groups were evident from a red shift of the amide I band by >7 cm-1 and an approximately five-fold reduction in amide hydrogen-deuterium exchange for peptide interacting with Cu2+ ions. Changes in the tertiary structure upon copper binding were also evident from the appearance of a new band at 1564 cm-1, which arises from the ring vibration of histidine. The copper-induced conformational change is pH dependent, and occurs at pH >7.
dc.identifier.issn0014-5793
dc.identifier.urihttp://hdl.handle.net/1885/65421
dc.publisherElsevier
dc.sourceFEBS Letters
dc.subjectKeywords: amide; copper; copper ion; deuterium; histidine; hydrogen; prion protein; article; conformational transition; hydrogen bond; infrared spectroscopy; marsupial; pH; priority journal; protein interaction; protein structure; Animals; Copper; Opossums; Prions; Copper binding; Fourier transform infrared spectroscopy; Marsupial protein; Prion protein; Repeat peptide; Secondary structure
dc.titleCopper-induced conformational change in a marsupial prion protein repeat peptide probed using FTIR spectroscopy
dc.typeJournal article
local.bibliographicCitation.issueFeb 13 (1-3)
local.bibliographicCitation.lastpage42
local.bibliographicCitation.startpage38
local.contributor.affiliationGustiananda, Marsia, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationHaris, Parvez I, De Montfort University
local.contributor.affiliationMilburn, Peter J, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationGready, Jill, College of Medicine, Biology and Environment, ANU
local.contributor.authoruidGustiananda, Marsia, u3186246
local.contributor.authoruidMilburn, Peter J, u8707729
local.contributor.authoruidGready, Jill, u9508375
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.absfor030606 - Structural Chemistry and Spectroscopy
local.identifier.absfor030499 - Medicinal and Biomolecular Chemistry not elsewhere classified
local.identifier.absfor110106 - Medical Biochemistry: Proteins and Peptides (incl. Medical Proteomics)
local.identifier.ariespublicationMigratedxPub1103
local.identifier.citationvolume512
local.identifier.doi10.1016/S0014-5793(01)03298-7
local.identifier.scopusID2-s2.0-0037070182
local.type.statusPublished Version

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