Specific binding of a β-cyclodextrin dimer to the amyloid β peptide modulates the peptide aggregation process
Date
2012
Authors
Wahlstrom, Anna
Cukalevski, Risto
Danielsson, Jens
Jarvet, Juri
Onagi, Hideki
Rebek, Julius (Jr.)
Linse, Sara
Graslund, Astrid
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Volume Title
Publisher
American Chemical Society
Abstract
Alzheimer's disease involves progressive neuronal loss. Linked to the disease is the amyloid β (Aβ) peptide, a 38-43-amino acid peptide found in extracellular amyloid plaques in the brain. Cyclodextrins are nontoxic, cone-shaped oligosaccharides with a
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Keywords
Keywords: Aggregation process; Alzheimer's disease; Amyloid plaques; Apparent k; Aromatic guests; Cone-shaped; Cyclodextrin dimers; Dissociation constant; Extracellular; Fibrillar aggregates; Flexible linkers; Heteronuclear; High concentration; Hydrophobic cavities
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Source
Biochemistry
Type
Journal article
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2037-12-31
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