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Specific binding of a β-cyclodextrin dimer to the amyloid β peptide modulates the peptide aggregation process

Wahlstrom, Anna; Cukalevski, Risto; Danielsson, Jens; Jarvet, Juri; Onagi, Hideki; Rebek, Julius (Jr.); Linse, Sara; Graslund, Astrid

Description

Alzheimer's disease involves progressive neuronal loss. Linked to the disease is the amyloid β (Aβ) peptide, a 38-43-amino acid peptide found in extracellular amyloid plaques in the brain. Cyclodextrins are nontoxic, cone-shaped oligosaccharides with a

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
URI: http://hdl.handle.net/1885/61556
Source: Biochemistry
DOI: 10.1021/bi300341j

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