Is human malarial coma caused, or merely deepened, by sequestration?
Date
2009
Authors
Clark, Ian A
Alleva, Lisa
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Volume Title
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Elsevier
Abstract
Much research into falciparum malaria coma assumes the primary event to be vascular obstruction by parasitized red blood cells. Recent evidence that vivax malaria, caused by a parasite traditionally thought not to block blood flow, seems to alter brain function to the same degree as falciparum malaria has seriously questioned this. These data are a timely call to reassess whether vascular obstruction should still be considered the primary cause of the coma of falciparum disease. They add to a growing literature that suggests that enhancement of brain-origin cytokines, such as tumour necrosis factor, by non-brain systemic inflammation and an appreciation of the degree to which neuronal homeostasis depends on them provide a more fruitful research direction.
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Keywords
Keywords: angiopoietin 2; cytokine; etanercept; tumor necrosis factor; tumor necrosis factor antibody; Alzheimer disease; article; brain blood flow; cerebrospinal fluid; clinical trial; coma; erythrocyte; human; India; inflammation; malaria falciparum; malarial com
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Source
Trends in Parasitology
Type
Journal article
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Restricted until
2037-12-31
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