Is human malarial coma caused, or merely deepened, by sequestration?

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dc.contributor.authorClark, Ian A
dc.contributor.authorAlleva, Lisa
dc.date.accessioned2015-12-10T22:17:14Z
dc.date.issued2009
dc.date.updated2016-02-24T10:54:39Z
dc.description.abstractMuch research into falciparum malaria coma assumes the primary event to be vascular obstruction by parasitized red blood cells. Recent evidence that vivax malaria, caused by a parasite traditionally thought not to block blood flow, seems to alter brain function to the same degree as falciparum malaria has seriously questioned this. These data are a timely call to reassess whether vascular obstruction should still be considered the primary cause of the coma of falciparum disease. They add to a growing literature that suggests that enhancement of brain-origin cytokines, such as tumour necrosis factor, by non-brain systemic inflammation and an appreciation of the degree to which neuronal homeostasis depends on them provide a more fruitful research direction.
dc.identifier.issn1471-4922
dc.identifier.urihttp://hdl.handle.net/1885/51311
dc.publisherElsevier
dc.sourceTrends in Parasitology
dc.subjectKeywords: angiopoietin 2; cytokine; etanercept; tumor necrosis factor; tumor necrosis factor antibody; Alzheimer disease; article; brain blood flow; cerebrospinal fluid; clinical trial; coma; erythrocyte; human; India; inflammation; malaria falciparum; malarial com
dc.titleIs human malarial coma caused, or merely deepened, by sequestration?
dc.typeJournal article
local.bibliographicCitation.issue7
local.bibliographicCitation.lastpage318
local.bibliographicCitation.startpage314
local.contributor.affiliationClark, Ian A, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationAlleva, Lisa, College of Medicine, Biology and Environment, ANU
local.contributor.authoremailrepository.admin@anu.edu.au
local.contributor.authoruidClark, Ian A, a261318
local.contributor.authoruidAlleva, Lisa, u9306857
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor060502 - Infectious Agents
local.identifier.ariespublicationu4325460xPUB221
local.identifier.citationvolume25
local.identifier.doi10.1016/j.pt.2009.04.003
local.identifier.scopusID2-s2.0-67649528611
local.identifier.uidSubmittedByu4325460
local.type.statusPublished Version

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