Sandow, Shaun L; Heydon, Katharina; Weible, Michael; Reynolds, Anna; Bartlett, Selena; Hendry, Ian
The retrograde axonal transport of neurotrophins occurs after receptor-mediated endocytosis into vesicles at the nerve terminal. We have been investigating the process of targeting these vesicles for retrograde transport, by examining the transport of [125I]-labelled neurotrophins from the eye to sympathetic and sensory ganglia. With the aid of confocal microscopy, we examined the phenomena further in cultures of dissociated I sympathetic ganglia to which rhodamine-labelled nerve growth factor...[Show more]
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