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Signalling organelle for retrograde axonal transport of internalized neurotrophins from the nerve terminal

Sandow, Shaun L; Heydon, Katharina; Weible, Michael; Reynolds, Anna; Bartlett, Selena; Hendry, Ian

Description

The retrograde axonal transport of neurotrophins occurs after receptor-mediated endocytosis into vesicles at the nerve terminal. We have been investigating the process of targeting these vesicles for retrograde transport, by examining the transport of [125I]-labelled neurotrophins from the eye to sympathetic and sensory ganglia. With the aid of confocal microscopy, we examined the phenomena further in cultures of dissociated I sympathetic ganglia to which rhodamine-labelled nerve growth factor...[Show more]

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
URI: http://hdl.handle.net/1885/34595
Source: Immunology and Cell Biology
DOI: 10.1046/j.1440-1711.2000.00924.x

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