Skip navigation
Skip navigation

Dicer-dependent microRNA pathway safeguards regulatory T cell function

Liston, Adrian; Lu, Li-Fan; O'Carroll, D C; Tarakhovsky, Alexander; Rudensky, Alexander

Description

Regulatory T (T reg) cells are indispensable for preventing autoimmunity. Incumbent to this role is the ability of T reg cells to exert their suppressor function under inflammatory conditions. We found that T reg cell-mediated tolerance is critically dependent on the Dicer-controlled microRNA (miRNA) pathway. Depletion of miRNA within the T reg cell lineage resulted in fatal autoimmunity indistinguishable from that in T reg cell-deficient mice. In disease-free mice lacking Dicer in all T cells...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
URI: http://hdl.handle.net/1885/32393
Source: Journal of Experimental Medicine
DOI: 10.1084/jem.20081062

Download

File Description SizeFormat Image
01_Liston_Dicer-dependent_microRNA_2008.pdf7.79 MBAdobe PDF    Request a copy


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  20 July 2017/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator