Dicer-dependent microRNA pathway safeguards regulatory T cell function
dc.contributor.author | Liston, Adrian | |
dc.contributor.author | Lu, Li-Fan | |
dc.contributor.author | O'Carroll, D C | |
dc.contributor.author | Tarakhovsky, Alexander | |
dc.contributor.author | Rudensky, Alexander | |
dc.date.accessioned | 2015-12-08T22:22:03Z | |
dc.date.issued | 2008 | |
dc.date.updated | 2015-12-08T08:40:43Z | |
dc.description.abstract | Regulatory T (T reg) cells are indispensable for preventing autoimmunity. Incumbent to this role is the ability of T reg cells to exert their suppressor function under inflammatory conditions. We found that T reg cell-mediated tolerance is critically dependent on the Dicer-controlled microRNA (miRNA) pathway. Depletion of miRNA within the T reg cell lineage resulted in fatal autoimmunity indistinguishable from that in T reg cell-deficient mice. In disease-free mice lacking Dicer in all T cells or harboring both Dicer-deficient and -sufficient T reg cells, Dicer-deficient T reg cells were suppressive, albeit to a lesser degree, whereas their homeostatic potential was diminished as compared with their Dicer-sufficient counterparts. However, in diseased mice, Dicer-deficient T reg cells completely lost suppressor capacity. Thus, miRNA preserve the T reg cell functional program under inflammatory conditions. | |
dc.identifier.issn | 0022-1007 | |
dc.identifier.uri | http://hdl.handle.net/1885/32393 | |
dc.publisher | Rockefeller University Press | |
dc.source | Journal of Experimental Medicine | |
dc.subject | Keywords: dicer; microRNA; animal experiment; animal tissue; article; autoimmunity; cell function; homeostasis; inflammation; mouse; nonhuman; priority journal; regulatory T lymphocyte; Animals; Apoptosis; Autoimmunity; Cell Lineage; Cell Proliferation; DEAD-box RN | |
dc.title | Dicer-dependent microRNA pathway safeguards regulatory T cell function | |
dc.type | Journal article | |
local.bibliographicCitation.issue | 9 | |
local.bibliographicCitation.lastpage | 2004 | |
local.bibliographicCitation.startpage | 1993 | |
local.contributor.affiliation | Liston, Adrian, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Lu, Li-Fan, University of Washington | |
local.contributor.affiliation | O'Carroll, D C, University of Washington | |
local.contributor.affiliation | Tarakhovsky, Alexander, The Rockefeller University | |
local.contributor.affiliation | Rudensky, Alexander, University of Washington | |
local.contributor.authoremail | repository.admin@anu.edu.au | |
local.contributor.authoruid | Liston, Adrian, u3937101 | |
local.description.embargo | 2037-12-31 | |
local.description.notes | Imported from ARIES | |
local.identifier.absfor | 110704 - Cellular Immunology | |
local.identifier.ariespublication | u6800332xPUB91 | |
local.identifier.citationvolume | 205 | |
local.identifier.doi | 10.1084/jem.20081062 | |
local.identifier.scopusID | 2-s2.0-51049110261 | |
local.identifier.uidSubmittedBy | u6800332 | |
local.type.status | Published Version |
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