Halliday, Jill I; Chebib, Mary; McLeod, Malcolm
A family of constrained acylated homocholine analogues have been synthesized, based on the azabicyclic ring scaffold derived from a double-Mannich annulation of cyclic ketones. The short synthetic route allows generation of structural diversity including, variation in the carbocyclic ring size, bridgehead substitution, nitrogen substitution and the ester sidechain. Biological assays on selected analogues demonstrate these compounds are nicotinic acetylcholine receptor (nAChR) antagonists....[Show more]
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.