Synthesis and biological evaluation of a new family of constrained azabicyclic homocholine analogues
dc.contributor.author | Halliday, Jill I | |
dc.contributor.author | Chebib, Mary | |
dc.contributor.author | McLeod, Malcolm | |
dc.date.accessioned | 2015-12-07T22:47:44Z | |
dc.date.issued | 2010 | |
dc.date.updated | 2016-02-24T09:51:32Z | |
dc.description.abstract | A family of constrained acylated homocholine analogues have been synthesized, based on the azabicyclic ring scaffold derived from a double-Mannich annulation of cyclic ketones. The short synthetic route allows generation of structural diversity including, variation in the carbocyclic ring size, bridgehead substitution, nitrogen substitution and the ester sidechain. Biological assays on selected analogues demonstrate these compounds are nicotinic acetylcholine receptor (nAChR) antagonists. Several analogues also bind to other neuronal transporter and receptor targets. | |
dc.identifier.issn | 0004-9425 | |
dc.identifier.uri | http://hdl.handle.net/1885/26176 | |
dc.publisher | CSIRO Publishing | |
dc.source | Australian Journal of Chemistry | |
dc.subject | Keywords: Azabicyclic ring; Biological assays; Biological evaluation; Carbocyclic rings; Cyclic ketones; Nicotinic acetylcholine receptors (nAChR); Receptor targets; Side-chain; Structural diversity; Synthetic routes; Esters; Ketones; Synthesis (chemical) | |
dc.title | Synthesis and biological evaluation of a new family of constrained azabicyclic homocholine analogues | |
dc.type | Journal article | |
local.bibliographicCitation.issue | 5 | |
local.bibliographicCitation.lastpage | 812 | |
local.bibliographicCitation.startpage | 808 | |
local.contributor.affiliation | Halliday, Jill I, University of Sydney | |
local.contributor.affiliation | Chebib, Mary, University of Sydney | |
local.contributor.affiliation | McLeod, Malcolm, College of Physical and Mathematical Sciences, ANU | |
local.contributor.authoremail | u4045340@anu.edu.au | |
local.contributor.authoruid | McLeod, Malcolm, u4045340 | |
local.description.embargo | 2037-12-31 | |
local.description.notes | Imported from ARIES | |
local.identifier.absfor | 030499 - Medicinal and Biomolecular Chemistry not elsewhere classified | |
local.identifier.absseo | 970103 - Expanding Knowledge in the Chemical Sciences | |
local.identifier.ariespublication | u2544221xPUB43 | |
local.identifier.citationvolume | 63 | |
local.identifier.doi | 10.1071/CH10024 | |
local.identifier.scopusID | 2-s2.0-77953015801 | |
local.identifier.thomsonID | 000277891900011 | |
local.identifier.uidSubmittedBy | u2544221 | |
local.type.status | Published Version |
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