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Galactose-functionalised PCL nanofibre scaffolds to attenuate inflammatory action of astrocytes in vitro and in vivo

Maclean, Francesca; Lau, Chew L; Ozergun, Sam; O'Shea, Ross D.; Cederfur, Cecilia; Wang, J; Healy, Kevin E; Walker, Frederick R.; Tomas, Doris; Horne, Malcolm K.; Beart, Philip M; Nisbet, David

Description

Astrocytes represent an attractive therapeutic target for the treatment of traumatic brain injury in the glial scar, which inhibits functional repair and recovery if persistent. Many biomaterial systems have been investigated for neural tissue engineering applications, including electrospun nanofibres, which are a favourable biomaterial as they can mimic the fibrous architecture of the extracellular matrix, and are conveniently modified to present biologically relevant cues to aid in...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
URI: http://hdl.handle.net/1885/218059
Source: Journal of Materials Chemistry B
DOI: 10.1039/c7tb00651a

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