Resolution and improved synthesis of (±)-arsenicin A: a natural adamantane-type tetraarsenical possessing strong anti-acute promelocytic leukemia cell line activity
Date
2012
Authors
Lu, Di
Coote, Michelle
Ho, Junming
Kilah, Nathan
Lin, Ching-Yeh
Salem, Geoffrey
Weir, Michelle
Willis, Anthony
Wild, Stanley (Bruce)
Dilda, Pierre J
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Volume Title
Publisher
American Chemical Society
Abstract
The resolution and improved synthesis of the naturally occurring, adamantane-type, tetraarsenical (±)-Arsenicin A is reported. The five-step synthesis of (±)-Arsenicin A from methylenebis(phenylarsinic acid) affords (±)-Arsenicin A as air-stable, color
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Keywords
Keywords: Air-stable; Asymmetric unit; Chiralpak IA; Colorless crystals; Enantiomeric purity; Glioblastomas; Gold standards; High-level ab initio calculations; Inorganic oxides; Inversion center; Leukemia cells; Methylene groups; Naturally occurring; Oxygen atom; P
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Source
Organometallics
Type
Journal article
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2037-12-31
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