Metastatic pancreatic ductal adenocarcinoma: diagnosis and treatment with a view to the future
Pokorny, Adrian M J; Chin, Venessa; Nagrial, Adnan M; Yip, Desmond; Chantrill, Lorraine
Metastatic pancreatic ductal adenocarcinoma (mPDAC) is a lethal disease with a poor 5-year survival. Systemic treatments can be used to control symptoms and prolong life. Cytotoxic chemotherapies are commonly administered, with combination treatments, such as fluorouracil, folinic acid, irinotecan and oxaliplatin (FOLFIRINOX) or nab paclitaxel and gemcitabine showing the largest clinical benefits. Newer genomic classifications of PDAC may provide a rationale for targeted therapies or...[Show more]
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