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Metastatic pancreatic ductal adenocarcinoma: diagnosis and treatment with a view to the future

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dc.contributor.authorPokorny, Adrian M J
dc.contributor.authorChin, Venessa
dc.contributor.authorNagrial, Adnan M
dc.contributor.authorYip, Desmond
dc.contributor.authorChantrill, Lorraine
dc.date.accessioned2020-01-02T03:33:41Z
dc.date.issued2018
dc.date.updated2019-08-04T08:21:23Z
dc.description.abstractMetastatic pancreatic ductal adenocarcinoma (mPDAC) is a lethal disease with a poor 5-year survival. Systemic treatments can be used to control symptoms and prolong life. Cytotoxic chemotherapies are commonly administered, with combination treatments, such as fluorouracil, folinic acid, irinotecan and oxaliplatin (FOLFIRINOX) or nab paclitaxel and gemcitabine showing the largest clinical benefits. Newer genomic classifications of PDAC may provide a rationale for targeted therapies or immunotherapies, although at present these remain largely experimental. This review discusses the evidence behind the currently used regimens, while introducing the potential future of pancreatic cancer care
dc.format.mimetypeapplication/pdfen_AU
dc.identifier.issn1444-0903en_AU
dc.identifier.urihttp://hdl.handle.net/1885/196459
dc.language.isoen_AUen_AU
dc.publisherWileyen_AU
dc.rights© 2018 Royal Australasian College of Physiciansen_AU
dc.sourceInternal Medicine Journalen_AU
dc.titleMetastatic pancreatic ductal adenocarcinoma: diagnosis and treatment with a view to the futureen_AU
dc.typeJournal articleen_AU
local.bibliographicCitation.issue6en_AU
local.bibliographicCitation.lastpage644en_AU
local.bibliographicCitation.startpage637en_AU
local.contributor.affiliationPokorny, Adrian M J, The Kinghorn Cancer Centreen_AU
local.contributor.affiliationChin, Venessa, The Kinghorn Cancer Centre, and the Cancer Research Programen_AU
local.contributor.affiliationNagrial, Adnan M, Crown Princess Mary Cancer Centreen_AU
local.contributor.affiliationYip, Desmond, College of Health and Medicine, ANUen_AU
local.contributor.affiliationChantrill, Lorraine, The Kinghorn Cancer Centre, and the Cancer Research Programen_AU
local.contributor.authoruidYip, Desmond, u5086006en_AU
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor111205 - Chemotherapyen_AU
local.identifier.absfor111207 - Molecular Targetsen_AU
local.identifier.absseo920102 - Cancer and Related Disordersen_AU
local.identifier.ariespublicationu5234101xPUB260en_AU
local.identifier.citationvolume48en_AU
local.identifier.doi10.1111/imj.13810en_AU
local.identifier.scopusID2-s2.0-85048359625
local.publisher.urlhttps://www.wiley.com/en-gben_AU
local.type.statusPublished Versionen_AU

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