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Toxicological studies of Orthosiphon stamineus (Misai Kucing) standardized ethanol extract in combination with gemcitabine in athymic nude mice model

Yehya, Ashwaq H S; Asif, Muhammad; Kaur, Gurjeet; Hassan, Loiy Ahmed; Al-Suede, Fouad S.R.; Abdul Majid, Amin Malik Shah Bin; Oon, Chern Ein


Pancreatic cancer has the highest mortality rate among cancers due to its aggressive biology and lack of effective treatment. Gemcitabine, the first line anticancer drug has reduced efficacy due to acquired resistance. The current study evaluates the toxicological effects of Orthosiphon stamineus (O.s) and its marker compound (rosmarinic acid) in combination with gemcitabine. O.s (200 or 400 mg/kg/day) and rosmarinic acid (32 mg/kg/day) were administered orally and gemcitabine (10 mg/kg/3 days)...[Show more]

CollectionsANU Research Publications
Date published: 2019
Type: Journal article
Source: Journal of Advanced Research
DOI: 10.1016/j.jare.2018.05.006
Access Rights: Open Access


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