Toxicological studies of Orthosiphon stamineus (Misai Kucing) standardized ethanol extract in combination with gemcitabine in athymic nude mice model

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dc.contributor.authorYehya, Ashwaq H S
dc.contributor.authorAsif, Muhammad
dc.contributor.authorKaur, Gurjeet
dc.contributor.authorHassan, Loiy Ahmed
dc.contributor.authorAl-Suede, Fouad S.R.
dc.contributor.authorAbdul Majid, Amin Malik Shah Bin
dc.contributor.authorOon, Chern Ein
dc.date.accessioned2019-12-02T23:09:17Z
dc.date.available2019-12-02T23:09:17Z
dc.date.issued2019
dc.date.updated2019-06-23T08:17:01Z
dc.description.abstractPancreatic cancer has the highest mortality rate among cancers due to its aggressive biology and lack of effective treatment. Gemcitabine, the first line anticancer drug has reduced efficacy due to acquired resistance. The current study evaluates the toxicological effects of Orthosiphon stamineus (O.s) and its marker compound (rosmarinic acid) in combination with gemcitabine. O.s (200 or 400 mg/kg/day) and rosmarinic acid (32 mg/kg/day) were administered orally and gemcitabine (10 mg/kg/3 days) intraperitoneally either alone or in combination treatment for fourteen days. Parameters including blood serum biochemistry, hematology, myeloid-erythroid ratio, incident of lethality, and histopathological analysis of liver, kidney, and spleen tissues were studied. Neither, individual drugs/extract nor chemo-herbal combinations at tested doses induced any toxicity and damage to organs in nude mice when compared to control group. Toxicological data obtained from this study will help to select the best doses of chemo-herbal combination for future pancreatic xenograft tumor studies.en_AU
dc.format.mimetypeapplication/pdfen_AU
dc.identifier.issn2090-1232en_AU
dc.identifier.urihttp://hdl.handle.net/1885/187185
dc.language.isoen_AUen_AU
dc.provenance© 2018 Production and hosting by Elsevier B.V. on behalf of Cairo University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).en_AU
dc.publisherElsevier BVen_AU
dc.rights© 2018 Production and hosting by Elsevier B.V. on behalf of Cairo University.en_AU
dc.rights.licenseCC BY-NC-ND licenseen_AU
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_AU
dc.sourceJournal of Advanced Researchen_AU
dc.titleToxicological studies of Orthosiphon stamineus (Misai Kucing) standardized ethanol extract in combination with gemcitabine in athymic nude mice modelen_AU
dc.typeJournal articleen_AU
dcterms.accessRightsOpen Accessen_AU
local.bibliographicCitation.lastpage68en_AU
local.bibliographicCitation.startpage59en_AU
local.contributor.affiliationYehya, Ashwaq H S, University of Science Malaysiaen_AU
local.contributor.affiliationAsif, Muhammad, Government College Universityen_AU
local.contributor.affiliationKaur, Gurjeet, Universiti Sains Malaysiaen_AU
local.contributor.affiliationHassan, Loiy Ahmed, Universiti Sains Malaysiaen_AU
local.contributor.affiliationAl-Suede, Fouad S.R., Universiti Sains Malaysiaen_AU
local.contributor.affiliationAbdul Majid, Amin Malik Shah Bin, College of Health and Medicine, ANUen_AU
local.contributor.affiliationOon, Chern Ein, Universiti Sains Malaysiaen_AU
local.contributor.authoremailrepository.admin@anu.edu.auen_AU
local.contributor.authoruidAbdul Majid, Amin Malik Shah Bin, u1026638en_AU
local.description.notesImported from ARIESen_AU
local.identifier.absfor119900 - OTHER MEDICAL AND HEALTH SCIENCESen_AU
local.identifier.absseo860803 - Human Pharmaceutical Treatments (e.g. Antibiotics)en_AU
local.identifier.ariespublicationu3102795xPUB329en_AU
local.identifier.citationvolume15en_AU
local.identifier.doi10.1016/j.jare.2018.05.006en_AU
local.identifier.scopusID2-s2.0-85053600875
local.identifier.uidSubmittedByu3102795en_AU
local.publisher.urlhttps://www.elsevier.com/en-auen_AU
local.type.statusPublished Versionen_AU

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