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Erythrocyte β spectrin can be genetically targeted to protect mice from malaria

Lelliott, Patrick; Huang, Hong Ming; Dixon, Matthew W. A.; Namwar, Arman; Blanch, Adam. J; Rajagopal, Vijay; Tilley, Leann; Coban, Cevavyir; McMorran, Brendan; Foote, Simon; Burgio, Gaetan


The malaria parasite hijacks host erythrocytes to shield itself from the immune system and proliferate. Red blood cell abnormalities can provide protection from malaria by impeding parasite invasion and growth within the cell or by compromising the ability of parasites to avoid host clearance. Here, we describe 2 N-ethyl-N-nitrosourea–induced mouse lines, SptbMRI26194 and SptbMRI53426, containing single-point mutations in the erythrocyte membrane skeleton gene, b spectrin (Sptb), which exhibit...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
Source: Blood Advances
DOI: 10.1182/bloodadvances.2017009274
Access Rights: Open Access


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