Erythrocyte β spectrin can be genetically targeted to protect mice from malaria
-
Altmetric Citations
Lelliott, Patrick; Huang, Hong Ming; Dixon, Matthew W. A.; Namwar, Arman; Blanch, Adam. J; Rajagopal, Vijay; Tilley, Leann; Coban, Cevavyir; McMorran, Brendan; Foote, Simon; Burgio, Gaetan
Description
The malaria parasite hijacks host erythrocytes to shield itself from the immune system and proliferate. Red blood cell abnormalities can provide protection from malaria by impeding parasite invasion and growth within the cell or by compromising the ability of parasites to avoid host clearance. Here, we describe 2 N-ethyl-N-nitrosourea–induced mouse lines, SptbMRI26194 and SptbMRI53426, containing single-point mutations in the erythrocyte membrane skeleton gene, b spectrin (Sptb), which exhibit...[Show more]
Collections | ANU Research Publications |
---|---|
Date published: | 2018 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/164701 |
Source: | Blood Advances |
DOI: | 10.1182/bloodadvances.2017009274 |
Access Rights: | Open Access |
Download
File | Description | Size | Format | Image |
---|---|---|---|---|
01_Lelliott_Erythrocyte_%CE%B2_spectrin_can_be_2018.pdf | 1.57 MB | Adobe PDF |
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.
Updated: 17 November 2022/ Responsible Officer: University Librarian/ Page Contact: Library Systems & Web Coordinator