Local proliferation maintains a stable pool of tissue-resident memory T cells after antiviral recall responses
Date
2018-02
Authors
Park, Simone L
Zaid, Ali
Hor, Jyh Liang
Christo, Susan N
Prier, Julia E
Davies, Brooke
Alexandre, Yannick O
Gregory, Julia L
Russell, Tiffany A
Gebhardt, Thomas
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Nature
Abstract
Although tissue-resident memory T cells (TRM cells) are critical in fighting infection, their fate after local pathogen re-encounter is unknown. Here we found that skin TRM cells engaged virus-infected cells, proliferated in situ in response to local antigen encounter and did not migrate out of the epidermis, where they exclusively reside. As a consequence, secondary TRM cells formed from pre-existing TRM cells, as well as from precursors recruited from the circulation. Newly recruited antigen-specific or bystander TRM cells were generated in the skin without displacement of the pre-existing TRM cell pool. Thus, pre-existing skin TRM cell populations are not displaced after subsequent infections, which enables multiple TRM cell specificities to be stably maintained within the tissue.
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Nature immunology
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Journal article
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Open Access
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Submitted version / Pre-print