Local proliferation maintains a stable pool of tissue-resident memory T cells after antiviral recall responses

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dc.contributor.authorPark, Simone L
dc.contributor.authorZaid, Ali
dc.contributor.authorHor, Jyh Liang
dc.contributor.authorChristo, Susan N
dc.contributor.authorPrier, Julia E
dc.contributor.authorDavies, Brooke
dc.contributor.authorAlexandre, Yannick O
dc.contributor.authorGregory, Julia L
dc.contributor.authorRussell, Tiffany A
dc.contributor.authorGebhardt, Thomas
dc.contributor.authorCarbone, Francis R
dc.contributor.authorTscharke, David C
dc.contributor.authorHeath, William R
dc.contributor.authorMueller, Scott N
dc.contributor.authorMackay, Laura K
dc.date.accessioned2018-11-30T01:24:46Z
dc.date.available2018-11-30T01:24:46Z
dc.date.issued2018-02
dc.description.abstractAlthough tissue-resident memory T cells (TRM cells) are critical in fighting infection, their fate after local pathogen re-encounter is unknown. Here we found that skin TRM cells engaged virus-infected cells, proliferated in situ in response to local antigen encounter and did not migrate out of the epidermis, where they exclusively reside. As a consequence, secondary TRM cells formed from pre-existing TRM cells, as well as from precursors recruited from the circulation. Newly recruited antigen-specific or bystander TRM cells were generated in the skin without displacement of the pre-existing TRM cell pool. Thus, pre-existing skin TRM cell populations are not displaced after subsequent infections, which enables multiple TRM cell specificities to be stably maintained within the tissue.en_AU
dc.description.sponsorshipS.L.P. was supported by the University of Melbourne (Elizabeth and Vernon Puzey Postgraduate Scholarship). T.G. was supported by a fellowship from the Sylvia and Charles Viertel Charitable Foundation. This work was supported by the National Health and Medical Research Council of Australia (to S.N.M. and L.K.M.) and the Australian Research Council (to S.N.M.).en_AU
dc.formatapplication/pdfen_AU
dc.format.mimetypeapplication/pdfen_AU
dc.identifier.issn1529-2908en_AU
dc.identifier.urihttp://hdl.handle.net/1885/154230
dc.provenanceAuthor's Pre-print: green tick author can archive pre-print (ie pre-refereeing) Author's Post-print: grey tick subject to Restrictions below, author can archive post-print (ie final draft post-refereeing) Restrictions: 6 months embargo Publisher's Version/PDF: cross author cannot archive publisher's version/PDFen_AU
dc.publisherNatureen_AU
dc.sourceNature immunologyen_AU
dc.titleLocal proliferation maintains a stable pool of tissue-resident memory T cells after antiviral recall responsesen_AU
dc.typeJournal articleen_AU
dcterms.accessRightsOpen Accessen_AU
local.bibliographicCitation.issue2en_AU
local.bibliographicCitation.lastpage191en_AU
local.bibliographicCitation.startpage183-191en_AU
local.identifier.ariespublicationa383154xPUB9321
local.identifier.citationvolume19en_AU
local.identifier.doi10.1038/s41590-017-0027-5en_AU
local.identifier.essn1529-2916en_AU
local.identifier.uidSubmittedByu4368888en_AU
local.type.statusSubmitted Versionen_AU

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