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Drosophila ribosomal protein mutants control tissue growth non-autonomously via effects on the prothoracic gland and ecdysone

Lin, Jane; Mitchell, Naomi; Kalcina, Marina; Tchoubrieva, E; Stewart, Mary; Marygold, Steven; Walker, Cherryl; Thomas, George; Leevers, Sally; Pearson, Richard B; Quinn, Leonie; Hannan, Ross

Description

The ribosome is critical for all aspects of cell growth due to its essential role in protein synthesis. Paradoxically, many Ribosomal proteins (Rps) act as tumour suppressors in Drosophila and vertebrates. To examine how reductions in Rps could lead to tissue overgrowth, we took advantage of the observation that an RpS6 mutant dominantly suppresses the small rough eye phenotype in a cyclin E hypomorphic mutant (cycE JP). We demonstrated that the suppression of cycE JP by the RpS6 mutant is not...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
URI: http://hdl.handle.net/1885/153191
Source: PLoS Genetics
DOI: 10.1371/journal.pgen.1002408
Access Rights: Open Access

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