Towards Personalized Thrombosis Studies: <i>in situ</i> Mold-free Lithography of Physiological Stenosis in Circular Capillaries
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Lim, Yean J.
Li, Yongxiao
Gardiner, Elizabeth E.
Lee, Woei M.
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Chemical and Biological Microsystems Society
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Abstract
Stenotic blood vessels are like cylindrical tubes with undulating surfaces that generate highly unpredictable 3D micro-rheology. Using new adaptive optics and polygon scanning mirrors, we demonstrate precise and rapid in situ fabrication of customized stenosis in cylindrical glass capillaries. We showed that these personalized stenosis create highly non-uniform surface shear that impacts on localized thrombus growth and stability.
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MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences
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