IgG Antibody Responses Are Preferential Compared with IgM for Use as Serological Markers for Detecting Recent Exposure to <i>Plasmodium vivax</i> Infection
| dc.contributor.author | Longley, Rhea J. | en |
| dc.contributor.author | White, Michael T. | en |
| dc.contributor.author | Brewster, Jessica | en |
| dc.contributor.author | Liu, Zoe S.J. | en |
| dc.contributor.author | Bourke, Caitlin | en |
| dc.contributor.author | Takashima, Eizo | en |
| dc.contributor.author | Harbers, Matthias | en |
| dc.contributor.author | Tham, Wai Hong | en |
| dc.contributor.author | Healer, Julie | en |
| dc.contributor.author | Chitnis, Chetan E. | en |
| dc.contributor.author | Monteiro, Wuelton | en |
| dc.contributor.author | Lacerda, Marcus | en |
| dc.contributor.author | Sattabongkot, Jetsumon | en |
| dc.contributor.author | Tsuboi, Takafumi | en |
| dc.contributor.author | Mueller, Ivo | en |
| dc.date.accessioned | 2025-06-12T03:34:29Z | |
| dc.date.available | 2025-06-12T03:34:29Z | |
| dc.date.issued | 2021-05-22 | en |
| dc.description.abstract | To achieve malaria elimination, new tools are required to explicitly target Plasmodium vivax. Recently, a novel panel of P. vivax proteins were identified and validated as serological markers for detecting recent exposure to P. vivax within the last 9 months. In order to improve the sensitivity and specificity of these markers, immunoglobulin M (IgM) in addition to immunoglobulin G (IgG) antibody responses were compared with a down-selected panel of 20 P. vivax proteins. IgM was tested using archival plasma samples from observational cohort studies conducted in malaria-endemic regions of Thailand and Brazil. IgM responses to these proteins generally had poorer classification performance than IgG. | en |
| dc.description.status | Peer-reviewed | en |
| dc.format.extent | 5 | en |
| dc.identifier.issn | 2328-8957 | en |
| dc.identifier.other | ORCID:/0000-0001-7950-8699/work/218987871 | en |
| dc.identifier.scopus | 85118669660 | en |
| dc.identifier.uri | http://www.scopus.com/inward/record.url?scp=85118669660&partnerID=8YFLogxK | en |
| dc.identifier.uri | https://hdl.handle.net/1885/733760096 | |
| dc.language.iso | en | en |
| dc.rights | Publisher Copyright: © 2021 The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America. | en |
| dc.source | Open Forum Infectious Diseases | en |
| dc.subject | antibody | en |
| dc.subject | IgG | en |
| dc.subject | IgM | en |
| dc.subject | malaria | en |
| dc.subject | Plasmodium vivax | en |
| dc.subject | serological exposure markers | en |
| dc.subject | serology | en |
| dc.subject | surveillance | en |
| dc.title | IgG Antibody Responses Are Preferential Compared with IgM for Use as Serological Markers for Detecting Recent Exposure to <i>Plasmodium vivax</i> Infection | en |
| dc.type | Journal article | en |
| dspace.entity.type | Publication | en |
| local.contributor.affiliation | Longley, Rhea J.; Walter and Eliza Hall Institute of Medical Research | en |
| local.contributor.affiliation | White, Michael T.; Institut Pasteur Paris | en |
| local.contributor.affiliation | Brewster, Jessica; Walter and Eliza Hall Institute of Medical Research | en |
| local.contributor.affiliation | Liu, Zoe S.J.; Walter and Eliza Hall Institute of Medical Research | en |
| local.contributor.affiliation | Bourke, Caitlin; Walter and Eliza Hall Institute of Medical Research | en |
| local.contributor.affiliation | Takashima, Eizo; Ehime University | en |
| local.contributor.affiliation | Harbers, Matthias; RIKEN | en |
| local.contributor.affiliation | Tham, Wai Hong; University of Melbourne | en |
| local.contributor.affiliation | Healer, Julie; University of Melbourne | en |
| local.contributor.affiliation | Chitnis, Chetan E.; Institut Pasteur Paris | en |
| local.contributor.affiliation | Monteiro, Wuelton; Fundacão de Medicina Tropical Dr Heitor Vieira Dourado | en |
| local.contributor.affiliation | Lacerda, Marcus; Fundação Oswaldo Cruz | en |
| local.contributor.affiliation | Sattabongkot, Jetsumon; Mahidol University | en |
| local.contributor.affiliation | Tsuboi, Takafumi; Ehime University | en |
| local.contributor.affiliation | Mueller, Ivo; Walter and Eliza Hall Institute of Medical Research | en |
| local.identifier.citationvolume | 8 | en |
| local.identifier.doi | 10.1093/ofid/ofab228 | en |
| local.identifier.pure | b7c6ae95-1997-4ccd-ba47-5dbb6b6798b6 | en |
| local.identifier.url | https://www.scopus.com/pages/publications/85118669660 | en |
| local.type.status | Published | en |