IgG Antibody Responses Are Preferential Compared with IgM for Use as Serological Markers for Detecting Recent Exposure to <i>Plasmodium vivax</i> Infection
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Longley, Rhea J.
White, Michael T.
Brewster, Jessica
Liu, Zoe S.J.
Bourke, Caitlin
Takashima, Eizo
Harbers, Matthias
Tham, Wai Hong
Healer, Julie
Chitnis, Chetan E.
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To achieve malaria elimination, new tools are required to explicitly target Plasmodium vivax. Recently, a novel panel of P. vivax proteins were identified and validated as serological markers for detecting recent exposure to P. vivax within the last 9 months. In order to improve the sensitivity and specificity of these markers, immunoglobulin M (IgM) in addition to immunoglobulin G (IgG) antibody responses were compared with a down-selected panel of 20 P. vivax proteins. IgM was tested using archival plasma samples from observational cohort studies conducted in malaria-endemic regions of Thailand and Brazil. IgM responses to these proteins generally had poorer classification performance than IgG.
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Open Forum Infectious Diseases
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