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Characterization of the stability and bio-functionality of tethered proteins on bioengineered scaffolds: Implications for stem cell biology and tissue repair

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dc.contributor.authorWang, Ting Yien
dc.contributor.authorBruggeman, Kiara A.F.en
dc.contributor.authorSheean, Rebecca K.en
dc.contributor.authorTurner, Bradley J.en
dc.contributor.authorNisbet, David R.en
dc.contributor.authorParish, Clare L.en
dc.date.accessioned2026-01-01T12:42:24Z
dc.date.available2026-01-01T12:42:24Z
dc.date.issued2014en
dc.description.abstractBackground: Tethering proteins onto bioengineered scaffolds enables longterm delivery, however protein stability, release kinetics, and functionality over time remains unknown. Results: Tethered proteins remain stable and functional for several months, capable of activating intracellular signaling pathways and influencing cell fate. Conclusion: Tethered proteins are stable and functional long-term. Significance: Such knowledge may have implications for promoting tissue repair.en
dc.description.statusPeer-revieweden
dc.format.extent8en
dc.identifier.issn0021-9258en
dc.identifier.otherPubMed:24700461en
dc.identifier.otherORCID:/0000-0002-1865-100X/work/162953051en
dc.identifier.scopus84901386353en
dc.identifier.urihttps://hdl.handle.net/1885/733800466
dc.language.isoenen
dc.sourceJournal of Biological Chemistryen
dc.titleCharacterization of the stability and bio-functionality of tethered proteins on bioengineered scaffolds: Implications for stem cell biology and tissue repairen
dc.typeJournal articleen
dspace.entity.typePublicationen
local.bibliographicCitation.lastpage15051en
local.bibliographicCitation.startpage15044en
local.contributor.affiliationWang, Ting Yi; University of Melbourneen
local.contributor.affiliationBruggeman, Kiara A.F.; School of Engineering, ANU College of Systems and Society, The Australian National Universityen
local.contributor.affiliationSheean, Rebecca K.; University of Melbourneen
local.contributor.affiliationTurner, Bradley J.; University of Melbourneen
local.contributor.affiliationNisbet, David R.; Department of Cancer Biology and Therapeutics, John Curtin School of Medical Research, ANU College of Science and Medicine, The Australian National Universityen
local.contributor.affiliationParish, Clare L.; University of Melbourneen
local.identifier.citationvolume289en
local.identifier.doi10.1074/jbc.M113.537381en
local.identifier.puredac5549c-3802-4a0e-a208-e2381ac53389en
local.identifier.urlhttps://www.scopus.com/pages/publications/84901386353en
local.type.statusPublisheden

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