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Characterization of the stability and bio-functionality of tethered proteins on bioengineered scaffolds: Implications for stem cell biology and tissue repair

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Date

2014

Authors

Wang, Ting Yi
Bruggeman, Kiara A.F.
Sheean, Rebecca K.
Turner, Bradley J.
Nisbet, David R.
Parish, Clare L.

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Abstract

Background: Tethering proteins onto bioengineered scaffolds enables longterm delivery, however protein stability, release kinetics, and functionality over time remains unknown. Results: Tethered proteins remain stable and functional for several months, capable of activating intracellular signaling pathways and influencing cell fate. Conclusion: Tethered proteins are stable and functional long-term. Significance: Such knowledge may have implications for promoting tissue repair.

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URI

https://hdl.handle.net/1885/733800466

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ANU Research Publications

Source

Journal of Biological Chemistry

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Journal article

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Publication

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DOI

10.1074/jbc.M113.537381

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