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Multiple binding modes with DNA of anthracene-9-carbonyl-N<sup>1</sup>-spermine probed by LD, CD, normal absorption, and molecular modelling compared with those of spermidine and spermine

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dc.contributor.authorAdlam, Garethen
dc.contributor.authorBlagbrough, Ian S.en
dc.contributor.authorTaylor, Stevenen
dc.contributor.authorLatham, Harriet C.en
dc.contributor.authorHaworth, Ian S.en
dc.contributor.authorRodger, Alisonen
dc.date.accessioned2026-01-02T22:40:57Z
dc.date.available2026-01-02T22:40:57Z
dc.date.issued1994en
dc.description.abstractDNA groove-binding and intercalative binding modes of anthracene-9-carbonyl-N1-spermine have been probed using linear and circular dichroism, and normal absorption techniques. Despite its lower positive charge, anthracene-9-carbonyl-N1-spermine stabilises DNA more than does spermine and significantly more than spermidine. Data interpretation has been facilitated by molecular modelling.en
dc.description.statusPeer-revieweden
dc.format.extent6en
dc.identifier.issn0960-894Xen
dc.identifier.otherORCID:/0000-0002-7111-3024/work/162949239en
dc.identifier.scopus0028150637en
dc.identifier.urihttps://hdl.handle.net/1885/733803239
dc.language.isoenen
dc.sourceBioorganic and Medicinal Chemistry Lettersen
dc.titleMultiple binding modes with DNA of anthracene-9-carbonyl-N<sup>1</sup>-spermine probed by LD, CD, normal absorption, and molecular modelling compared with those of spermidine and spermineen
dc.typeJournal articleen
dspace.entity.typePublicationen
local.bibliographicCitation.lastpage2440en
local.bibliographicCitation.startpage2435en
local.contributor.affiliationAdlam, Gareth; University of Bathen
local.contributor.affiliationBlagbrough, Ian S.; University of Bathen
local.contributor.affiliationTaylor, Steven; University of Bathen
local.contributor.affiliationLatham, Harriet C.; University of Bathen
local.contributor.affiliationHaworth, Ian S.; University of Bathen
local.contributor.affiliationRodger, Alison; University of Bathen
local.identifier.citationvolume4en
local.identifier.doi10.1016/S0960-894X(01)80405-4en
local.identifier.pure2d8e2961-bbf5-47d8-9aef-b5815edb5774en
local.identifier.urlhttps://www.scopus.com/pages/publications/0028150637en
local.type.statusPublisheden

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