Multiple binding modes with DNA of anthracene-9-carbonyl-N¹-spermine probed by LD, CD, normal absorption, and molecular modelling compared with those of spermidine and spermine

Abstract

DNA groove-binding and intercalative binding modes of anthracene-9-carbonyl-N1-spermine have been probed using linear and circular dichroism, and normal absorption techniques. Despite its lower positive charge, anthracene-9-carbonyl-N1-spermine stabilises DNA more than does spermine and significantly more than spermidine. Data interpretation has been facilitated by molecular modelling. Show more