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Multiple binding modes with DNA of anthracene-9-carbonyl-N<sup>1</sup>-spermine probed by LD, CD, normal absorption, and molecular modelling compared with those of spermidine and spermine

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Date

1994

Authors

Adlam, Gareth
Blagbrough, Ian S.
Taylor, Steven
Latham, Harriet C.
Haworth, Ian S.
Rodger, Alison

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Research Projects

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Abstract

DNA groove-binding and intercalative binding modes of anthracene-9-carbonyl-N1-spermine have been probed using linear and circular dichroism, and normal absorption techniques. Despite its lower positive charge, anthracene-9-carbonyl-N1-spermine stabilises DNA more than does spermine and significantly more than spermidine. Data interpretation has been facilitated by molecular modelling.

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Citation

URI

https://hdl.handle.net/1885/733803239

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ANU Research Publications

Source

Bioorganic and Medicinal Chemistry Letters

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Journal article

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Publication

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DOI

10.1016/S0960-894X(01)80405-4

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