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The structure of the homeodomain and its functional implications

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dc.contributor.authorGehring, W. J.en
dc.contributor.authorMüller, M.en
dc.contributor.authorAffolter, M.en
dc.contributor.authorPercival-Smith, A.en
dc.contributor.authorBilleter, M.en
dc.contributor.authorQian, Y. Q.en
dc.contributor.authorOtting, G.en
dc.contributor.authorWüthrich, K.en
dc.date.accessioned2026-03-01T17:40:43Z
dc.date.available2026-03-01T17:40:43Z
dc.date.issued1990en
dc.description.abstractThe three-dimensional structure of the homeodomain, as determined by nuclear magnetic resonance spectroscopy, reveals the presence of a helix-turn-helix motif, similar to the one found in prokaryotic gene regulatory proteins. Isolated homeodomains bind with high affinity to specific DNA sequences. Thus, the structure-function relationship is highly conserved in evolution.en
dc.description.statusPeer-revieweden
dc.format.extent7en
dc.identifier.issn0168-9525en
dc.identifier.otherPubMed:1980756en
dc.identifier.otherORCID:/0000-0002-0563-0146/work/206892047en
dc.identifier.scopus0025008350en
dc.identifier.urihttps://hdl.handle.net/1885/733806827
dc.language.isoenen
dc.sourceTrends in Geneticsen
dc.titleThe structure of the homeodomain and its functional implicationsen
dc.typeJournal articleen
dspace.entity.typePublicationen
local.bibliographicCitation.lastpage329en
local.bibliographicCitation.startpage323en
local.contributor.affiliationGehring, W. J.; University of Baselen
local.contributor.affiliationMüller, M.; University of Baselen
local.contributor.affiliationAffolter, M.; University of Baselen
local.contributor.affiliationPercival-Smith, A.; University of Baselen
local.contributor.affiliationBilleter, M.; Swiss Federal Institute of Technology Zurichen
local.contributor.affiliationQian, Y. Q.; Swiss Federal Institute of Technology Zurichen
local.contributor.affiliationOtting, G.; Swiss Federal Institute of Technology Zurichen
local.contributor.affiliationWüthrich, K.; Swiss Federal Institute of Technology Zurichen
local.identifier.citationvolume6en
local.identifier.doi10.1016/0168-9525(90)90253-3en
local.identifier.pure658226c0-1a8a-478d-87aa-d6796100e5a2en
local.identifier.urlhttps://www.scopus.com/pages/publications/0025008350en
local.type.statusPublisheden

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