The structure of the homeodomain and its functional implications
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Gehring, W. J.
Müller, M.
Affolter, M.
Percival-Smith, A.
Billeter, M.
Qian, Y. Q.
Otting, G.
Wüthrich, K.
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Abstract
The three-dimensional structure of the homeodomain, as determined by nuclear magnetic resonance spectroscopy, reveals the presence of a helix-turn-helix motif, similar to the one found in prokaryotic gene regulatory proteins. Isolated homeodomains bind with high affinity to specific DNA sequences. Thus, the structure-function relationship is highly conserved in evolution.
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Trends in Genetics
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