Stereocontrolled aldol additions to α-methylene-β-alkoxy aldehydes: Application to the synthesis of a C<sub>13</sub>C<sub>25</sub> segment of bafilomycin A<sub>1</sub>
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Paterson, Ian
Bower, Shelley
McLeod, Malcolm D.
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A boron-mediated, syn-aldol coupling between ethyl ketone 8 and aldehyde 9, followed by directed hydrogenation at C16 and acetonide hydrolysis, gives the C13C25 segment 6 of bafilomycin A1.
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Tetrahedron Letters
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