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Novel folding and stability defects cause a deficiency of human glutathione transferase omega 1

Date

Authors

Zhou, Huina

Brock, Joseph

Casarotto, Marco

Oakley, Aaron

Board, Philip

Publisher

American Society for Biochemistry and Molecular Biology Inc

Abstract

The polymorphic deletion of Glu-155 from human glutathione transferase omega1 (GSTO1-1) occurs in most populations. Although the recombinant ΔGlu-155 enzyme expressed in Escherichia coli is active, the deletion causes a deficiency of the active enzyme in

Keywords

Keywords: Free energy change; Glutathione transferase; Human cells; In-vivo; Intermediate state; Intrinsic fluorescence; Refolding; Slow phase; Solvent accessibility; Stern-Volmer constants; Surface area; Three-state models; Wild types; Defects; Enzymes; Escherichi

URI

http://hdl.handle.net/1885/58587

Collections

ANU Research Publications

Source

Journal of Biological Chemistry

Type

Journal article

Access Statement

Open Access

DOI

10.1074/jbc.M110.197822

Downloads

File

Description

01_Zhou_Novel_folding_and_stability_2011.pdf (1.91 MB)

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