The identification and structural characterization of C7orf24 as γ-glutamyl cyclotransferase: an essential enzyme in the γ-glutamyl cycle

Oakley, Aaron; Yamada, Tetsuo; Liu, Dan; Coggan, Marjorie; Clark, Alan; Board, Philip

The identification and structural characterization of C7orf24 as γ-glutamyl cyclotransferase: an essential enzyme in the γ-glutamyl cycle

Date

2008

Authors

Oakley, Aaron

Yamada, Tetsuo

Liu, Dan

Coggan, Marjorie

Clark, Alan

Board, Philip

Publisher

American Society for Biochemistry and Molecular Biology Inc

Abstract

The hypothetical protein C7orf24 has been implicated as a cancer marker with a potential role in cell proliferation. We have identified C7orf24 as γ-glutamyl cyclotransferase (GGCT) that catalyzes the formation of 5-oxoproline (pyroglutamic acid) from γ