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Cytokines, Skin, and Smallpox-A new link to an antimicrobial peptide

Date

Authors

Harrison, Jodie

Ramshaw, Ian

Publisher

Cell Press

Abstract

Patients with atopic dermatitis (AD) have an increased risk of infection with several viruses compared to patients with other inflammatory skin disorders such as psoriasis. In this issue of Immunity, Howell et al. (2006) find that the cytokine milieu in the skin of AD patients profoundly affects the innate response to vaccinia virus (VV) by blocking production of the antimicrobial peptide LL-37.

Keywords

Keywords: alpha1 interferon; antimicrobial peptide ll 37; beta1 interferon; cathelicidin; cathelin; cell protein; cytokine; defensin; gamma interferon; immunoglobulin enhancer binding protein; interleukin 13; interleukin 4; smallpox vaccine; STAT6 protein; unclassi

URI

http://hdl.handle.net/1885/78091

Collections

ANU Research Publications

Source

Immunity

Type

Journal article

DOI

10.1016/j.immuni.2006.03.003

Restricted until

2037-12-31

Downloads

File

Description

01_Harrison_Cytokines,_Skin,_and_2006.pdf (82.37 KB)