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The three-dimensional structural surface of two beta-sheet scorpion toxins mimics that of an alpha helical dihydropyridine receptor segment

Date

2003

Authors

Green, Daniel
Pace, Suzy M
Curtis, Suzanne
Sakowska, Magdalena
Lamb, Graham
Dulhunty, Angela
Casarotto, Marco

Journal Title

Journal ISSN

Volume Title

Publisher

Portland Press

Abstract

An α-helical II-III loop segment of the dihydropyridine receptor activates the ryanodine receptor calcium-release channel. We describe a novel manipulation in which this agonist's activity is increased by modifying its surface structure to resemble that

Description

Keywords

Keywords: Calcium; Catalyst activity; Muscle; Surface structure; Thermodynamic properties; Toxic materials; Sheet scorpion toxins; Biochemistry; 1,4 dihydropyridine receptor; calcium channel; ryanodine receptor; scorpion venom; article; beta sheet; binding affinity Ion channel; NMR; Peptide A; Ryanodine receptor

Citation

Source

Biochemical Journal

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1042/BJ20021488

Restricted until

2037-12-31