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Calothrixins A and B, Novel Pentacyclic Metabolites from Calothrix Cyanobacteria with Potent Activity against Malaria Parasites and Human Cancer Cells

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dc.contributor.authorRickards, Rodney
dc.contributor.authorRothschild, Jennifer
dc.contributor.authorWillis, Anthony
dc.contributor.authorde Chazel, Nola
dc.contributor.authorKirk, J
dc.contributor.authorKirk, Kiaran
dc.contributor.authorSaliba, Kevin
dc.contributor.authorSmith, Geoffrey D
dc.date.accessioned2015-12-13T23:24:06Z
dc.date.issued1999
dc.date.updated2015-12-12T09:19:08Z
dc.description.abstractCell extracts from photoautrophic cultures of two cyanobacterial Calothrix isolates inhibited the growth in vitro of a chloroquine-resistant strain of the malaria parasite, Plasmodium falciparum, and of human HeLa cancer cells, in a dose-dependent manner. Bioassay-directed fractionation of the extracts led to the isolation and structural characterization of calothrixins A (1) and B (2), pentacyclic metabolites with an indolo[3,2- j]phenanthridine ring system unique amongst natural products, which exert their growth-inhibitory effects at nanomolar concentrations.
dc.identifier.issn0040-4020
dc.identifier.urihttp://hdl.handle.net/1885/92065
dc.publisherElsevier
dc.sourceTetrahedron
dc.subjectKeywords: calothrixin a; calothrixin b; indole derivative; phenanthridine derivative; unclassified drug; article; bacterium culture; bacterium isolate; cancer cell; cyanobacterium; drug isolation; drug structure; hela cell; human; human cell; malaria; nonhuman; pla Anticancer; Antiplasmodial; Cyanobacteria; Polycyclic heterocyclic compounds
dc.titleCalothrixins A and B, Novel Pentacyclic Metabolites from Calothrix Cyanobacteria with Potent Activity against Malaria Parasites and Human Cancer Cells
dc.typeJournal article
local.bibliographicCitation.lastpage13520
local.bibliographicCitation.startpage13513
local.contributor.affiliationRickards, Rodney, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationRothschild, Jennifer, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationWillis, Anthony, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationde Chazel, Nola, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationKirk, J, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationKirk, Kiaran, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationSaliba, Kevin, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationSmith, Geoffrey D, College of Medicine, Biology and Environment, ANU
local.contributor.authoruidRickards, Rodney, v000238
local.contributor.authoruidRothschild, Jennifer, u7100617
local.contributor.authoruidWillis, Anthony, u8512028
local.contributor.authoruidde Chazel, Nola, u8611117
local.contributor.authoruidKirk, J, u980631
local.contributor.authoruidKirk, Kiaran, u9608579
local.contributor.authoruidSaliba, Kevin, u9707744
local.contributor.authoruidSmith, Geoffrey D, u7200037
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.absfor060502 - Infectious Agents
local.identifier.absfor111502 - Clinical Pharmacology and Therapeutics
local.identifier.ariespublicationMigratedxPub23040
local.identifier.citationvolume55
local.identifier.doi10.1016/S0040-4020(99)00833-9
local.identifier.scopusID2-s2.0-0033585089
local.type.statusPublished Version

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