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3-Mercapto-1,2,4-triazoles and N-acylated thiosemicarbazides as metallo-β-lactamase inhibitors

Date

Authors

Faridoon, Mr

Hussein, Waleed M

Vella, Peter

Ul Islam, Nazar

Ollis, David

Schenk, Gerhard

McGeary, Ross Peter

Publisher

Pergamon-Elsevier Ltd

Abstract

The production of β-lactamases is an effective strategy by which pathogenic bacteria can develop resistance against β-lactam antibiotics. While inhibitors of serine-β-lactamases are widely used in combination therapy with β-lactam antibiotics, there a

Keywords

Keywords: 3 mercapto 1,2,4 triazole derivative; beta lactam antibiotic; beta lactamase inhibitor; captopril; imipenemase inhibitor; n acylated thiosemicarbazide; thiosemicarbazide derivative; triazole derivative; unclassified drug; article; controlled study; drug p 3-Mercapto-1,2,4-triazoles; Antibiotic resistance; Inhibition assays; Metallo-ß-lactamases; Thiosemicarbazides

URI

http://hdl.handle.net/1885/60712

Collections

ANU Research Publications

Source

Bioorganic and Medicinal Chemistry Letters

Type

Journal article

DOI

10.1016/j.bmcl.2011.10.116

Restricted until

2037-12-31

Downloads

File

Description

01_Faridoon_3-Mercapto-1,2,4-triazoles_and_2012.pdf (2.25 MB)