A First Generation Chemoenzymatic Synthesis of (+)-Galanthamine
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Banwell, Martin
Ma, Xinghua
Karunaratne, Ochitha
Willis, Anthony
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CSIRO Publishing
Abstract
A total synthesis of (+)-galanthamine [(+)-1] has been achieved using the readily available and enantiomerically pure metabolite 2 as starting material. The quaternary carbon centre (C8a) associated with target 1 was constructed using the EschenmoserClaisen rearrangement reaction.
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Australian Journal of Chemistry
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2037-12-31
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