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Caffeine sensitivity of native RyR channels from normal and malignant hyperthermic pigs: effects of a DHPR II-III loop peptide

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Gallant, Esther
Hart, James
Eager, Kevin
Curtis, Suzanne
Dulhunty, Angela

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American Physiological Society

Abstract

Enhanced sensitivity to caffeine is part of the standard tests for susceptibility to malignant hyperthermia (MH) in humans and pigs. The caffeine sensitivity of skeletal muscle contraction and Ca2+ release from the sarcoplasmic reticulum is enhanced, but

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American Journal of Physiology - Cell Physiology

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