Caffeine sensitivity of native RyR channels from normal and malignant hyperthermic pigs: effects of a DHPR II-III loop peptide

Gallant, Esther; Hart, James; Eager, Kevin; Curtis, Suzanne; Dulhunty, Angela

Caffeine sensitivity of native RyR channels from normal and malignant hyperthermic pigs: effects of a DHPR II-III loop peptide

Date

2004

Authors

Gallant, Esther

Hart, James

Eager, Kevin

Curtis, Suzanne

Dulhunty, Angela

Publisher

American Physiological Society

Abstract

Enhanced sensitivity to caffeine is part of the standard tests for susceptibility to malignant hyperthermia (MH) in humans and pigs. The caffeine sensitivity of skeletal muscle contraction and Ca2+ release from the sarcoplasmic reticulum is enhanced, but

Keywords

Keywords: 1,4 dihydropyridine receptor; arginine; C peptide; caffeine; calcium; cysteine; peptide; ryanodine receptor; peptide fragment; phosphodiesterase inhibitor; animal experiment; article; calcium homeostasis; calcium transport; controlled study; disease predi Calcium ion homeostasis; Excitation-contraction coupling; Muscle contraction; Ryanodine receptor polymorphisms

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http://hdl.handle.net/1885/85940

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ANU Research Publications

Source

American Journal of Physiology - Cell Physiology

Type

Journal article

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Caffeine sensitivity of native RyR channels from normal and malignant hyperthermic pigs: effects of a DHPR II-III loop peptide

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