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Insight into the molecular recognition of spermine by DNA quadruplexes from an NMR study of the association of spermine with the thrombin-binding aptamer

Date

Authors

Keniry, Max

Owen, Elisabeth

Publisher

John Wiley & Sons Inc

Abstract

The preferred residence sites and the conformation of DNA-bound polyamines are central to understanding the regulatory roles of polyamines. To this end, we have used a series of selective 13C-edited and selective total correlation spectroscopy-edited one-

Keywords

Keywords: aptamer; guanine quadruplex; spermine; thrombin aptamer; article; chemical structure; chemistry; conformation; methodology; nuclear magnetic resonance spectroscopy; Aptamers, Nucleotide; G-Quadruplexes; Magnetic Resonance Spectroscopy; Models, Molecular; DNA; DNA quadruplex; NMR spectroscopy; spermine; thrombin-binding aptamer

URI

http://hdl.handle.net/1885/62010

Collections

ANU Research Publications

Source

Journal of Molecular Recognition

Type

Journal article

DOI

10.1002/jmr.2274

Restricted until

2037-12-31

Downloads

File

Description

01_Keniry_Insight_into_the_molecular_2013.pdf (968.42 KB)

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