The impact of high-intensity interval training exercise on breast cancer survivors: A pilot study to explore fitness, cardiac regulation and biomarkers of the stress systems
dc.contributor.author | Toohey, Kellie | |
dc.contributor.author | Pumpa, Kate L | |
dc.contributor.author | McKune, Andrew J | |
dc.contributor.author | Cooke, Julie | |
dc.contributor.author | Welvaert, Marijke | |
dc.contributor.author | Northey, Joseph | |
dc.contributor.author | Quinlan, Clare | |
dc.contributor.author | Semple, Stuart J. | |
dc.date.accessioned | 2022-07-29T04:29:08Z | |
dc.date.available | 2022-07-29T04:29:08Z | |
dc.date.issued | 2020 | |
dc.date.updated | 2021-08-01T08:24:37Z | |
dc.description.abstract | Background Cardiovascular disease (CVD) remains the largest cause of death in breast cancer survivors. The aim of this study was to explore the impact of exercise intensity on aerobic fitness and autonomic cardiac regulation (heart rate variability (HRV)) and salivary biomarkers of the stress systems (HPA-axis, cortisol; sympathetic nervous system, α-amylase) and mucosal immunity (secretory(s)-IgA), markers of increased risk of CVD in breast cancer survivors. Methods Participants were randomly assigned to; 1) high intensity interval training (HIIT); 2) moderate-intensity, continuous aerobic training (CMIT); or 3) a wait-list control (CON) for a 12-week (36 session) stationary cycling intervention. Cardiorespiratory fitness (VO2peak), resting HRV and salivary biomarkers were measured at baseline 2-4 d pre-intervention and 2-4 d post the last exercise session. Results Seventeen participants were included in this study (62 +- 8 years, HIIT; n = 6, CMIT; n = 5, CON; n = 6). A significant improvement (p ≤ 0.05) was observed for VO2peak in the HIIT group; 19.3% (B = 3.98, 95%CI = [1.89; 4.02]) and a non-significant increase in the CMIT group; 5.6% (B = 1.96, 95%CI = [− 0.11; 4.03]), compared with a 2.6% (B = − 0.64, 95%CI = [− 2.10; 0.82]) decrease in the CON group. Post intervention improvements in HRV markers of vagal activity (log (ln)LF/HF, LnRMSSD) and sympathetic nervous system (α-amylase waking response) occurred for individuals exhibiting outlying (> 95% CI) levels at baseline compared to general population. Conclusion High intensity interval training improved cardiovascular fitness in breast cancer survivors and improved cardiac regulation, and sympathetic nervous system (stress) responses in some individuals. High-intensity interval training was safe and effective for breast cancer survivors to participate in with promising results as a time efficient intensity to improve physical health and stress, reducing CVD risk. | en_AU |
dc.format.mimetype | application/pdf | en_AU |
dc.identifier.issn | 1471-2407 | en_AU |
dc.identifier.uri | http://hdl.handle.net/1885/270046 | |
dc.language.iso | en_AU | en_AU |
dc.provenance | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data | en_AU |
dc.publisher | BioMed Central | en_AU |
dc.rights | © The Author(s). 2020 Open Access | en_AU |
dc.rights.license | Creative Commons Attribution 4.0 International License | en_AU |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_AU |
dc.source | BMC Cancer | en_AU |
dc.subject | Exercise | en_AU |
dc.subject | Cancer | en_AU |
dc.subject | Immune function | en_AU |
dc.subject | Biomarkers | en_AU |
dc.subject | High-intensity | en_AU |
dc.subject | Health | en_AU |
dc.subject | Stress | en_AU |
dc.title | The impact of high-intensity interval training exercise on breast cancer survivors: A pilot study to explore fitness, cardiac regulation and biomarkers of the stress systems | en_AU |
dc.type | Journal article | en_AU |
dcterms.accessRights | Open Access | en_AU |
local.bibliographicCitation.issue | 1 | en_AU |
local.bibliographicCitation.lastpage | 11 | en_AU |
local.bibliographicCitation.startpage | 1 | en_AU |
local.contributor.affiliation | Toohey, Kellie, University of Canberra | en_AU |
local.contributor.affiliation | Pumpa, Kate L, University of Canberra | en_AU |
local.contributor.affiliation | McKune, Andrew J, University of Canberra | en_AU |
local.contributor.affiliation | Cooke, Julie, University of Canberra | en_AU |
local.contributor.affiliation | Welvaert, Marijke, Administrative Portfolio, ANU | en_AU |
local.contributor.affiliation | Northey, Joseph, University of Canberra | en_AU |
local.contributor.affiliation | Quinlan, Clare, University of Canberra | en_AU |
local.contributor.affiliation | Semple, Stuart J., University of Canberra | en_AU |
local.contributor.authoremail | u1081520@anu.edu.au | en_AU |
local.contributor.authoruid | Welvaert, Marijke, u1081520 | en_AU |
local.description.notes | Imported from ARIES | en_AU |
local.identifier.absfor | 420701 - Biomechanics | en_AU |
local.identifier.ariespublication | a383154xPUB15210 | en_AU |
local.identifier.citationvolume | 20 | en_AU |
local.identifier.doi | 10.1186/s12885-020-07295-1 | en_AU |
local.identifier.scopusID | 2-s2.0-85089769996 | |
local.identifier.uidSubmittedBy | a383154 | en_AU |
local.publisher.url | http://www.biomedcentral.com/bmccancer/ | en_AU |
local.type.status | Published Version | en_AU |
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