Gating Mechanism of Mechanosensitive Ion Channels Studied by Continuum Mechanics

Date

2014

Authors

Bavi, Navid
Nomura, Takeshi
Qin, Qinghua
Martinac, Boris

Journal Title

Journal ISSN

Volume Title

Publisher

Biophysical Society

Abstract

To complement the existing experimental and computational methods used for studies of membrane protein structure and dynamics a finite element (FE) model for multi length-scale and time-scale investigations of the gating mechanism of mechanosensitive (MS) ion channels has been established. The main advantage of the FE simulation over molecular dynamic simulation is its flexibility in handling complex geometries and boundary conditions. In this study the FE model of MscL, the large conductance bacterial MS channel, has been developed as an initial template providing a continuum structural framework for a mechanistic understanding of the gating mechanism in MS channels, which can also be employed to develop structural dynamic models of other types of MS channels.

Description

Keywords

Citation

Source

Biophysical Journal

Type

Journal article

Book Title

Entity type

Access Statement

Open Access

License Rights

DOI

10.1016/j.bpj.2013.11.3085

Restricted until