Prohormone-substrate peptide sequence recognition by peptidylglycine α-amidating monooxygenase and its reflection in increased glycolate inhibitor potency
Date
2012
Authors
Morris, Kelly
Cao, Feihua (Lucy)
Onagi, Hideki
Altamore, Timothy
Gamble, Allan
Easton, Christopher
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Volume Title
Publisher
Pergamon-Elsevier Ltd
Abstract
The interactions of nineteen peptide substrates and fifteen analogous peptidomimetic glycolate inhibitors with human peptidylglycine α-amidating monooxygenase (PAM) have been investigated. The substrates and inhibitors are the prohormones of calcitonin a
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Keywords
Keywords: alpha amidating enzyme; antineoplastic agent; calcitonin; enzyme inhibitor; glycolic acid; oxytocin; peptidomimetic glycolate inhibitor; peptidylglycine alpha amidating monooxygenase inhibitor; unclassified drug; amino acid sequence; antineoplastic activi Glycolate inhibitors; Human cancer; Peptide substrates; Peptidylglycine a-amidating monooxygenase; Prohormones
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Source
Bioorganic and Medicinal Chemistry Letters
Type
Journal article
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Restricted until
2037-12-31
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