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Prohormone-substrate peptide sequence recognition by peptidylglycine α-amidating monooxygenase and its reflection in increased glycolate inhibitor potency

Date

2012

Authors

Morris, Kelly
Cao, Feihua (Lucy)
Onagi, Hideki
Altamore, Timothy
Gamble, Allan
Easton, Christopher

Journal Title

Journal ISSN

Volume Title

Publisher

Pergamon-Elsevier Ltd

Abstract

The interactions of nineteen peptide substrates and fifteen analogous peptidomimetic glycolate inhibitors with human peptidylglycine α-amidating monooxygenase (PAM) have been investigated. The substrates and inhibitors are the prohormones of calcitonin a

Description

Keywords

Keywords: alpha amidating enzyme; antineoplastic agent; calcitonin; enzyme inhibitor; glycolic acid; oxytocin; peptidomimetic glycolate inhibitor; peptidylglycine alpha amidating monooxygenase inhibitor; unclassified drug; amino acid sequence; antineoplastic activi Glycolate inhibitors; Human cancer; Peptide substrates; Peptidylglycine a-amidating monooxygenase; Prohormones

Citation

Source

Bioorganic and Medicinal Chemistry Letters

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1016/j.bmcl.2012.10.004

Restricted until

2037-12-31