Toward a better understanding of ADHD: LPHN3 gene variants and the susceptibility to develop ADHD

Date

2010

Authors

Arcos-Burgos, Mauricio
Muenke, Maximilian

Journal Title

Journal ISSN

Volume Title

Publisher

Springer

Abstract

During the past 15 years, an impressive amount of genetic information has become available in the research field of psychiatry, particularly as it relates to attentiondeficit/ hyperactivity disorder (ADHD). However, the classical clinical approach to ADHD has minimally affected and not significantly been improved by this genetic revolution. It is difficult to predict how long it will take for genetic findings to alter the way clinicians treat patients with ADHD. New medications or treatment protocols may take years to become routine clinical practice. However, when taken together, recent successes in genomics, pharmacogenomics, and genetic epidemiology have the potential (1) to prevent comorbid consequences of ADHD, (2) to individualize therapies for patients with ADHD, and (3) to define new epidemiological policies to aid with the impact of ADHD on society. Here, we present an overview of how genetic research may affect and improve the quality of life of patients withADHD: as an example, we use the discovery of LPHN3, a new gene in which variants have recently been shown to be associated with ADHD.

Description

Keywords

Keywords: G protein coupled receptor; article; attention deficit disorder; attributable risk; comorbidity; gene; gene function; gene linkage disequilibrium; gene locus; genetic association; genetic marker; genetic risk; genetic susceptibility; genetic variability; Adhd; Complex trait; Gene; Genetics; Latrophilin; Lphn3

Citation

Source

Attention Deficit and Hyperactivity Disorders - ADHD

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1007/s12402-010-0030-2

Restricted until

2037-12-31