Organoarsenic probes to study proteins by NMR spectroscopy

Date

2022-01-13

Authors

Mahawaththa, Mithun
Orton, Henry
Adekoya, Ibidolapo
Huber, Thomas
Otting, Gottfried
Nitsche, Christoph

Journal Title

Journal ISSN

Volume Title

Publisher

Royal Society of Chemistry

Abstract

Arsenical probes enable structural studies of proteins. We report the first organoarsenic probes for nuclear magnetic resonance (NMR) and electron paramagnetic resonance (EPR) spectroscopy to study proteins in solutions. These probes can be attached to irregular loop regions. A lanthanide-binding tag induces sizable pseudocontact shifts in protein NMR spectra of a magnitude never observed for small paramagnetic probes before.

Description

Keywords

nuclear magnetic resonance, biomolecular

Citation

Source

Chemical communications

Type

Journal article

Book Title

Entity type

Access Statement

Open Access

License Rights

DOI

10.1039/d1cc06497e

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