Organoarsenic probes to study proteins by NMR spectroscopy
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Mahawaththa, Mithun
Orton, Henry
Adekoya, Ibidolapo
Huber, Thomas
Otting, Gottfried
Nitsche, Christoph
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Royal Society of Chemistry
Abstract
Arsenical probes enable structural studies of proteins. We report the first organoarsenic probes for nuclear magnetic resonance (NMR) and electron paramagnetic resonance (EPR) spectroscopy to study proteins in solutions. These probes can be attached to irregular loop regions. A lanthanide-binding tag induces sizable pseudocontact shifts in protein NMR spectra of a magnitude never observed for small paramagnetic probes before.
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Chemical communications
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Open Access