Organoarsenic probes to study proteins by NMR spectroscopy
Date
2022-01-13
Authors
Mahawaththa, Mithun
Orton, Henry
Adekoya, Ibidolapo
Huber, Thomas
Otting, Gottfried
Nitsche, Christoph
Journal Title
Journal ISSN
Volume Title
Publisher
Royal Society of Chemistry
Abstract
Arsenical probes enable structural studies of proteins. We report the first organoarsenic probes for nuclear magnetic resonance (NMR) and electron paramagnetic resonance (EPR) spectroscopy to study proteins in solutions. These probes can be attached to irregular loop regions. A lanthanide-binding tag induces sizable pseudocontact shifts in protein NMR spectra of a magnitude never observed for small paramagnetic probes before.
Description
Keywords
nuclear magnetic resonance, biomolecular
Citation
Collections
Source
Chemical communications
Type
Journal article
Book Title
Entity type
Access Statement
Open Access