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3D structure determination of a protein in living cells using paramagnetic NMR spectroscopy

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Date

2016-08-11

Authors

Pan, Bin-Bin
Yang, Feng
Ye, Yansheng
Wu, Qiong
Li, Conggang
Huber, Thomas
Su, Xun-Cheng

Journal Title

Journal ISSN

Volume Title

Publisher

Abstract

Determining the three-dimensional structure of a protein in living cells remains particularly challenging. We demonstrated that the integration of site-specific tagging proteins and GPS-Rosetta calculations provides a fast and effective way of determining the structures of proteins in living cells, and in principle the interactions and dynamics of protein-ligand complexes.

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Citation

URI

http://hdl.handle.net/1885/149440

Collections

ANU Research Publications

Source

Chemical communications (Cambridge, England)

Type

Journal article

Book Title

Entity type

Access Statement

Open Access

License Rights

DOI

10.1039/c6cc05490k

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