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Identification of novel membrane proteins by searching for patterns in hydropathy profiles

Date

Authors

Clements, John D

Martin, Rowena

Publisher

Blackwell Publishing Ltd

Abstract

A technique has been developed to search a proteome database for new members of a functional class of membrane protein. It takes advantage of the highly conserved secondary structure of functionally related membrane proteins. Such proteins typically have

Keywords

Keywords: 4 aminobutyric acid receptor; cholinergic receptor; glycine receptor; ionotropic receptor; membrane protein; neurotransmitter; proteome; serotonin receptor; article; data base; priority journal; protein analysis; sequence alignment; sequence homology; Dat Hydropathy profile; Integral membrane protein; Ligand-gated channel; Neurotransmitter receptor; Proteomics; Transporter

URI

http://hdl.handle.net/1885/94600

Collections

ANU Research Publications

Source

European Journal of Biochemistry

Type

Journal article

DOI

10.1046/j.1432-1033.2002.02859.x

Restricted until

2037-12-31

Downloads

File

Description

01_Clements_Identification_of_novel_2002.pdf (247.7 KB)

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